Maternal obesity and metabolic risk to the offspring: why lifestyle interventions may have not achieved the desired outcomes

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Maternal Obesity, Metabolic Health, and Prenatal Programming of Offspring Obesity

Children born to overweight and obese women, as compared to those of normal weight women, have greater risk for becoming obese themselves and suffering comorbid metabolic health problems. Evidence is accumulating that this increased susceptibility is at least partially attributed to a prenatal programming effect, whereby obesogenic factors in the intrauterine environment alter fetal development...

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Maternal obesity results in offspring prone to metabolic syndrome.

Obesity is reaching epidemic proportions in industrialized and developing countries. The main factors that determine the growing pandemic of obesity are changes in lifestyle leading to a reduced physical activity and increased sedentarism together with an increased richfat food intake. Obesity is a risk factor for many diseases such as type 2 diabetes, cardiovascular risk and stroke, hyperchole...

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Maternal obesity increases the risk of metabolic disease and impacts renal health in offspring

Obesity, together with insulin resistance, promotes multiple metabolic abnormalities and is strongly associated with an increased risk of chronic disease including type 2 diabetes (T2D), hypertension, cardiovascular disease, non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). The incidence of obesity continues to rise in astronomical proportions throughout the world and ...

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Maternal obesity and risk of Down syndrome in the offspring.

OBJECTIVE The objective of this article is to determine if maternal obesity is associated with an increased risk of Down syndrome in the offspring and whether the risk estimates for trisomy 21 based on combined screening is affected by maternal body mass index (BMI). METHODS Study group I consisted of a nationwide cohort of 1 568 604 women giving birth; outcome was infants born with Down synd...

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Lifestyle interventions to reduce cancer risk and improve outcomes.

There are more than one half million cancer deaths in the United States each year, and one third of these deaths are attributed to suboptimal diet and physical activity practices. Maintaining a healthy weight, staying physically active throughout life, and consuming a healthy diet can substantially reduce the lifetime risk of developing cancer, as well as influence overall health and survival a...

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ژورنال

عنوان ژورنال: International Journal of Obesity

سال: 2015

ISSN: 0307-0565,1476-5497

DOI: 10.1038/ijo.2015.15